The landscape of cardiovascular disease (CVD) is undergoing a significant transformation, thanks to a groundbreaking presidential advisory from the American Heart Association. This advisory highlights the intricate connections among cardiovascular disease, kidney disease, Type 2 diabetes, and obesity. It proposes a redefined approach to CVD risk assessment, prevention, and management that takes these interactions into account. This paradigm shift, outlined in the Circulation journal, introduces the concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome.